Proteomic changes in mammalian spermatozoa during epididymal maturation
نویسندگان
چکیده
منابع مشابه
Proteomic changes in mammalian spermatozoa during epididymal maturation.
Epididymal maturation is associated with the activation of a cAMP-induced tyrosine phosphorylation cascade, which is ultimately associated with the expression of capacitation-dependent sperm functions, such as hyperactivated movement and acrosomal exocytosis. As spermatozoa progress through the epididymis they first acquire the capacity to phosphorylate tyrosine on targets on the principal piec...
متن کاملChanges in calmodulin level and cAMP-dependent protein kinase activity during epididymal maturation of ram spermatozoa.
Calmodulin concentration and cAMP-dependent protein kinase activity were simultaneously determined on ram spermatozoa collected by cannulation of successive segments of the epididymal tubule. Epididymal transit was characterized on one hand by an overall decrease in the calmodulin level and on the other by a dramatic rise in the cAMP-dependent protein kinase activity. In contrast to the calmodu...
متن کاملThiol changes during epididymal maturation: a link to flagellar angulation in mouse spermatozoa?
Caput epididymal wild-type spermatozoa and cauda epididymal spermatozoa from mice null for the adenylyl cyclase Adcy10 gene are immotile unless stimulated by a membrane-permeant cyclic AMP analogue. Both types of spermatozoa exhibit flagellar angulation where the head folds back under these conditions. As sperm proteins undergo oxidation of sulfhydryl groups and the flagellum becomes more stabl...
متن کاملChanges in Mithun (Bos frontalis) spermatozoa during epididymal passage.
Genital organs of 10 healthy, adult Mithun bulls (6-8 years old) that were slaughtered at the dwellings of tribal people for meat were collected. Immediately after collection, spermatozoa from 3 different regions of the epididymis, i.e. the head, body and tail, were obtained to study morphological changes of the spermatozoa during passage through these regions. The prevalence of proximal cytopl...
متن کاملMorphological and acrosomal changes of canine spermatozoa during epididymal transit
BACKGROUND During epididymal transit, functional and structural modifications leading to full maturation enable male gametes to reach, recognize and fertilize the oocytes. In dogs, little is known on the modifications of spermatozoa during the passage in the epididymis. The aim of this study was to describe the motility, morphology and acrosomal patterns of canine spermatozoa retrieved from the...
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ژورنال
عنوان ژورنال: Asian Journal of Andrology
سال: 2007
ISSN: 1008-682X,1745-7262
DOI: 10.1111/j.1745-7262.2007.00280.x